Total combining power: Technique for the evaluation of the quality control process of clostridiosis vaccines
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- 作者：Igor Viana Brandia ; ibrandi@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; ibrandi@ica.ufmg.br" class="auth_mail" title="E-mail the corresponding author ; Eliane Macedo Sobrinho Santosb ; Bruna Mara Aparecida de Carvalhoa ; Carla Adriana Ferreira Durã ; esa ; Paula Karoline Soares Fariasa ; Roger Shoji Saria ; Alex Sander Rodrigues Cangussuc ; Adalberto Pessoa Juniord
- 关键词：International antitoxin unit (I.U.) ; The quantity of epsilon antitoxin that reacts with Lo and L ; + doses of standard toxin according to their definitions ; Lo dose ; The largest quantity of toxin that can be mixed with one-tenth unit of standard antitoxin and not cause sickness or death when injected into mice ; L ; + dose ; The smallest quantity of toxin that can be mixed with one-tenth unit of standard antitoxin and cause death in at least 80% of injected mice ; Standard epsilon antitoxin
- 刊名：Journal of Microbiological Methods
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：130
- 期：Complete
- 页码：164-168
- 全文大小：260 K
文摘
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Total combining power (TCP) allows accurate measurement of toxoid concentration.
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TCP can control the process of development and production of toxoid-based vaccines.
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Suitable TCP values ensure production of antibodies in vaccinated animals.
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Use of TCP for process control is more efficient compared to LD50 and L +.
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TCP is specific, selective, and applicable to process control in vaccine production.