Diverging role for coronin 1 in antiviral CD4⁺ and CD8⁺ T cell responses

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• 作者：Vincent Sam Yong Tchang ; Andrea Mekker ; Kerstin Siegmund ; Urs Karrer ; Jean Pieters
• 关键词：LCMV ; lymphocytic choriomeningitis virus ; VSV ; vesicular stomatitis virus ; DTH ; delayed type hypersensitivity ; PFU ; plaque forming unit
• 刊名：Molecular Immunology
• 出版年：2013
• 出版时间：31 December, 2013
• 年：2013
• 卷：56
• 期：4
• 页码：683-692
• 全文大小：1968 K

文摘

Coronin 1 is a member of the evolutionary conserved WD repeat protein family and is highly expressed in hematopoietic cells. Coronin 1 is essential for Ca²⁺ mobilization upon T cell receptor (TCR) stimulation providing a pro-survival signal for na?ve peripheral T cells. Both in mouse and in human, coronin 1 deficiency is associated with severe T cell lymphopenia. In this work, we have analyzed antiviral T cell-mediated immunity in the presence and absence of coronin 1 in vivo after infection with lymphocytic choriomenigitis virus (LCMV) and vesicular stomatitis virus (VSV) in mice. Despite low peripheral T cell numbers we found that LCMV-specific CD8⁺ T cell responses were normal in the absence of coronin 1 and kinetics of LCMV-clearance were similar compared to wild type mice. In contrast, CD4⁺ T cell responses were profoundly decreased after LCMV- and VSV-infection. We propose that coronin 1 plays a differential role in CD8⁺ versus CD4⁺ T cell responses and activation.