¦Á-Methoxymethyl ketones via aldol reaction

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• 作者：Alex ; er Kasal ; Milos Budesinsky
• 关键词：NMR ; Steroids ; Synthesis ; Aldol reaction
• 刊名：Tetrahedron
• 出版年：2013
• 出版时间：18 November, 2013
• 年：2013
• 卷：69
• 期：46
• 页码：9663-9674
• 全文大小：547 K

文摘

Paraformaldehyde in a methanolic solution of KOH converts ketones into ¦Á-methoxymethylated and ¦Á- hydroxymethylated products. The method was tested on nine steroidal ketones. On prolonged treatment the ketones formed are reduced to alcohols.