Synthesis of labeled meropenem for the analysis of M. tuberculosis transpeptidases

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• 作者：David B. Kastrinsky ; Clifton E. Barry III
• 刊名：Tetrahedron Letters
• 出版年：2010
• 出版时间：6 January 2010
• 年：2010
• 卷：51
• 期：1
• 页码：197-200
• 全文大小：296 K

文摘

A concise synthesis of ¹⁴C labeled meropenem prepared from ¹⁴C dimethylamine hydrochloride is described. Using a similar reaction sequence, the meropenem nucleus was also attached to biotin providing a probe for protein interaction studies.