Pre-Existing Right Bundle Branch Block Increases Risk for Death After Transcatheter Aortic Valve Replacement With a Balloon-Expandable Valve

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• 作者：Yusuke Watanabe ; MD^a ; ^{yusuke0831@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Ken Kozuma ; MD ; PhD^a ; Hirofumi Hioki ; MD^a ; Hideyuki Kawashima ; MD ; PhD^a ; Yugo Nara ; MD^a ; Akihisa Kataoka ; MD ; PhD^a ; Fukuko Nagura ; MD^a ; Makoto Nakashima ; MD^a ; Shinichi Shirai ; MD^b ; Norio Tada ; MD^c ; Motoharu Araki ; MD^d ; Kensuke Takagi ; MD^e ; Futoshi Yamanaka ; MD^f ; Masanori Yamamoto ; MD ; PhD^g ; ^h ; Kentaro Hayashida ; MD ; PhDⁱ
• 关键词：cardiac death ; RBBB ; transcatheter aortic valve replacement
• 刊名：JACC: Cardiovascular Interventions
• 出版年：2016
• 出版时间：14 November 2016
• 年：2016
• 卷：9
• 期：21
• 页码：2210-2216
• 全文大小：568 K

文摘

The aim of this study was to determine the impact of pre-existing right bundle branch block (RBBB) on clinical outcomes after transcatheter aortic valve replacement (TAVR).

Background

The impact of pre-existing RBBB on clinical outcomes after TAVR is unknown.

Methods

Between October 2013 and August 2015, 749 patients undergoing TAVR using the Edwards SAPIEN XT prosthesis were prospectively enrolled in the OCEAN-TAVI (Optimized Transcatheter Valvular Intervention) registry from 8 Japanese centers. Electrocardiograms were obtained at baseline. After the procedure, follow-up outpatient visits or telephone interviews were conducted at 30 days, 6 months, and yearly.

Results

A total of 102 patients (13.6%) had pre-existing RBBB. The incidence of new pacemaker implantation was significantly higher in the RBBB group (17.6% vs. 2.9%; p < 0.01). The Kaplan-Meier analysis revealed that cardiovascular survival probability was significantly lower in the RBBB group than the no-RBBB group (log-rank p < 0.01). Patients with RBBB and without pacemakers were at higher risk for cardiovascular mortality in the early phase after discharge, and patients with RBBB and pacemakers had higher cardiovascular mortality at mid-term follow-up (log-rank p = 0.01). A multivariate Cox regression model indicated that pre-existing RBBB (hazard ratio: 2.59; 95% confidence interval: 1.15 to 5.85; p < 0.01) was an independent predictor of cardiovascular mortality.

Conclusions

Patients with RBBB demonstrated an increased risk for cardiovascular mortality after TAVR, and patients with RBBB and without pacemakers were at higher risk for cardiac death early after discharge. Patients with prior RBBB should be carefully monitored after undergoing TAVR.