Prebiotics and age, but not probiotics affect the transformation of 2-amino-3-methyl-3H-imidazo[4,5-f]quinoline (IQ) by fecal microbiota - An in vitro study
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- 作者：Adriana Nowaka ; adriana.nowak@p.lodz.pl" class="auth_mail" title="E-mail the corresponding author ; Agata Czyżowskaa ; Krzysztof Hubenb ; Michał Só ; jkac ; Sławomir Kuberskid ; Anna Otlewskaa ; Katarzyna Śliżewskaa
- 关键词：Probiotics ; Prebiotics ; Ageing ; 7-OH-IQ ; Fecal microbiota ; NMR ; LC-MSn ; FTIR
- 刊名：Anaerobe
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：39
- 期：Complete
- 页码：124-135
- 全文大小：1404 K
文摘
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7-OH-IQ formation depends on the age of the person, and is more likely to occur in humans with unstable microbiota (the elderly).
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Enterococcus faecium, Enterococcus faecalis and Clostridium difficileconvert IQ to 7-OH-IQ.
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The genotoxicity of samples containing 7-OH-IQ is three times higher than those with IQ.
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Probiotic strains are not involved in IQ conversion.
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7-OH-IQ is not detected in the presence of the following prebiotics: Frutafit HD, lactulose, Raftilose P95 and resistant dextrin.