Flavonolignan 2,3-dehydroderivatives: Preparation, antiradical and cytoprotective activity
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- 作者：Michaela Pyszková ; a ; Michal Bilerb ; c ; David Biedermannd ; Kateřina Valentová ; d ; Marek Kuzmad ; Jiří ; Vrbaa ; Jitka Ulrichová ; a ; Romana Sokolová ; e ; Milo&scaron ; Mojovićf ; Ana Popović-Bijelićf ; Martin Kubalab ; Patrick Trouillasc ; g ; Vladimí ; r Křend ; Jan Vaceka ; jan.vacek@upol.cz" class="auth_mail" title="E-mail the corresponding author
- 关键词：Flavonolignans ; Antioxidants ; Oxidation ; Aryloxy radicals ; Electron transfer ; Hydrogen transfer
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：90
- 期：Complete
- 页码：114-125
- 全文大小：2964 K
文摘
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Redox and antioxidant properties of silymarin flavonolignans are rationalized.
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Comprehensive mechanistic in vitro and in silico study is presented.
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Study includes silybin, silychristin, silydianin and 2,3-dehydro derivatives.
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Cytoprotective action of flavonolignans is described in HepG2 cells.
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Antioxidant vs. prooxidant effects of flavonolignans are discussed.