Inflammation in adult women with a history of child maltreatment: The involvement of mitochondrial alterations and oxidative stress
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- 作者：Christina Boecka ; christina.boeck@uni-ulm.de" class="auth_mail" title="E-mail the corresponding author ; Alexandra Maria Koeniga ; Katharina Schurya ; Martha Leonie Geigera ; Alexander Karabatsiakisa ; Sarah Wilkera ; Christiane Wallerb ; Harald Gü ; ndelb ; Jö ; rg Michael Fegertc ; Enrico Calziad ; Iris-Tatjana Kolassaa
- 关键词：Child maltreatment ; Stress ; Inflammation ; Mitochondria ; Oxidative stress ; Metabolomics
- 刊名：Mitochondrion
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：30
- 期：Complete
- 页码：197-207
- 全文大小：876 K
文摘
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Experiencing maltreatment during childhood (CM) has life-long health consequences.
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We study inflammatory processes associated with a history of CM in adult women.
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ROS production, oxidative stress and mitochondrial activity were increased with CM.
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Mitochondrial activity was positively associated with pro-inflammatory cytokine release.
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Findings indicated higher inflammasome activation with increasing severity of CM.