Efficient Stem Cell Collection after Modified Cisplatin-Based Mobilization Chemotherapy in Patients with Diffuse Large B Cell Lymphoma
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- 作者：Katharina Lisenko1 ; Martin Cremer1 ; Mark-Alexander Schwarzbich1 ; Mark Kriegsmann2 ; Anthony D. Ho1 ; Mathias Witzens-Harig1 ; Patrick Wuchter1 ; patrick.wuchter@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：R-DHAP ; Diffuse large B cell lymphoma ; Leukapheresis ; Autologous stem cell transplantation
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：22
- 期：8
- 页码：1397-1402
- 全文大小：470 K
文摘
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Analysis of 65 patients with DLBCL receiving R-DHAP as a salvage regimen.
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Modified R-DHAP with administration of cisplatin over 4 consecutive days.
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Overall response rate (CR, CRu, PR) of 66% after 1 to 2 cycles.
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Modified R-DHAP regimen efficiently mobilizes CD34+ cells for PBSC collection.
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PBSC harvest after the first cycle of R-DHAP yielded significantly more CD34+ cells.