- 作者：Maria-de-Gracia Dominguez ; Helen L. Fisher ; Barnaby Major ; Brock Chisholm ; Nikola Rahaman ; John Joyce ; James Woolley ; Jo Lawrence ; Mark Hinton ; Karl Marlowe ; Katherine Aitchison ; Sonia Johnson ; Matthew Hodes
- 关键词：Adolescence ; First episode psychosis ; Duration of untreated psychosis ; Ethnicity ; Cannabis ; Age of onset
- 刊名：Schizophrenia Research
- 出版年：November, 2013
- 年：2013
- 卷：150
- 期：2-3
- 页码：526-532
- 全文大小：532 K
Background
Duration of Untreated Psychosis (DUP) is an important measure associated with outcome of psychosis. This first study in the UK compared DUP between adolescent and adult-onset individuals and explored whether the adolescent-onset group showed variations in DUP that could be accounted for by sociodemographic and selected risk factors.Methods
This naturalistic cohort study included 940 new first-episode psychosis cases aged 14-35 years (136 adolescent-onset versus 804 adult-onset psychotic individuals) referred to nine Early Intervention Services for Psychosis in London (2003-2009). Sociodemographic characteristics, age of onset, family history of mental illness, duration of untreated psychosis, suicidality and substance use information were collected at entry to the services.
Results
Adolescents presented with significantly greater median DUP (179 days) than adults (81 days, p = 0.005). Large differences in DUP were found amongst adolescent ethnic groups (median DUP: White: 454 days; Black: 103 days; Asian and mixed: 28.5 days). In addition, younger age of onset and higher lifetime cannabis use were associated with longer treatment delay amongst adolescents.
Conclusions
This study of DUP in adolescent-onset psychosis found it to be approximately twice the length of DUP amongst adults. For the adolescent White sub-group, DUP was far greater than the UK Department of Health target (< 3 months). Both the high rates of lifetime cannabis use and the lower age of onset might explain the long DUP in this ethnic group. Physicians need to be particularly vigilant about identifying and managing early psychosis in adolescents.