Effects of Mediterranean diet on sexual function in people with newly diagnosed type 2 diabetes: The MÈDITA trial

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• 作者：Maria Ida Maiorino^a ; ^{mariaida.maiorino@unina2.it" class="auth_mail" title="E-mail the corresponding author} ; Giuseppe Bellastella^a ; ^{giuseppe.bellastella@unina2.it" class="auth_mail" title="E-mail the corresponding author} ; Mariangela Caputo^a ; ^{marycapu_2008@libero.it" class="auth_mail" title="E-mail the corresponding author} ; Filomena Castaldo^a ; ^{castaldomena@libero.it" class="auth_mail" title="E-mail the corresponding author} ; Maria Rosaria Improta^a ; ^{improtasaria@libero.it" class="auth_mail" title="E-mail the corresponding author} ; Dario Giugliano^a ; ^{dario.giugliano@unina2.it" class="auth_mail" title="E-mail the corresponding author} ; Katherine Esposito^b ; ^{katherine.esposito@unina2.it" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Mediterranean diet ; Type 2 diabetes ; ED ; Female sexual dysfunction ; Randomized controlled trial
• 刊名：Journal of Diabetes and its Complications
• 出版年：2016
• 出版时间：November-December 2016
• 年：2016
• 卷：30
• 期：8
• 页码：1519-1524
• 全文大小：312 K

文摘

To assess the long-term effect of Mediterranean diet, as compared with low-fat diet, on sexual function in patients with newly diagnosed type 2 diabetes.

Methods

In a randomized clinical trial, with a total follow-up of 8.1 years, 215 men and women with newly diagnosed type 2 diabetes were assigned to Mediterranean diet (n = 108) or a low-fat diet (n = 107). The primary outcome measures were changes of erectile function (IIEF) in diabetic men and of female sexual function (FSFI) in diabetic women.

Results

There was no difference in baseline sexual function in men (n = 54 vs 52) or women (n = 54 vs 55) randomized to Mediterranean diet or low-fat diet, respectively (P = 0.287, P = 0.815). Over the entire follow-up, the changes of the primary outcomes were significantly lower in the Mediterranean diet group compared with the low-fat group: IIEF and FSFI showed a significantly lesser decrease (1.22 and 1.18, respectively, P = 0.024 and 0.019) with the Mediterranean diet. Baseline C-reactive protein levels predicted erectile dysfunction in men but not female sexual dysfunction in women.

Conclusions

Among persons with newly diagnosed type 2 diabetes, a Mediterranean diet reduced the deterioration of sexual function over time in both sexes.