Dementia incidence declined in African-Americans but not in Yoruba

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• 作者：Sujuan Gao^a ; ^{sgao@iu.edu" class="auth_mail" title="E-mail the corresponding author} ; Adesola Ogunniyi^b ; Kathleen S. Hall^c ; Olusegun Baiyewu^d ; Frederick W. Unverzagt^c ; Kathleen A. Lane^a ; Jill R. Murrell^e ; Oye Gureje^d ; Ann M. Hake^f ; Hugh C. Hendrie^c ; ^g ; ^h
• 关键词：Dementia ; Alzheimer's disease ; Incidence ; African-Americans ; Nigerians
• 刊名：Alzheimer's & Dementia
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：12
• 期：3
• 页码：244-251
• 全文大小：681 K

文摘

To compare dementia incidence of African-American and Yoruba cohorts aged ≥70 years enrolled in 1992 and 2001.

Methods

African-Americans residing in Indianapolis and Yoruba in Ibadan, Nigeria without dementia were enrolled in 1992 and 2001 and evaluated every 2–3 years until 2009. The cohorts consist of 1440 African-Americans, 1774 Yoruba in 1992 and 1835 African-Americans and 1895 Yoruba in the 2001 cohorts aged ≥70 years.

Results

In African-Americans, dementia and Alzheimer's disease (AD) incidence rates were significantly lower in 2001 than 1992 for all age groups except the oldest group. The overall standardized annual dementia incidence rates were 3.6% (95% confidence interval [CI], 3.2%–4.1%) in the 1992 cohort and 1.4% (95% CI, 1.2%–1.7%) in the 2001 cohort. There was no significant difference in dementia or AD incidence between the Yoruba cohorts.

Discussion

Future research is needed to explore the reasons for the differential changes in incidence rates in these two populations.