Using a novel “Integrated Biomarker Proteomic‿index to assess the effects of freshwater pollutants in European eel peripheral blood mononuclear cells
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- 作者：Kathleen Rolanda ; Patrick Kestemonta ; Marc Dieub ; Martine Raesb ; Fré ; dé ; ric Silvestrea ; frederic.silvestre@unamur.be" class="auth_mail" title="E-mail the corresponding author
- 关键词：Anguilla anguilla ; Proteomics ; Biomarkers ; Cd ; DDT ; Integrated Biomarker Proteomic index ; Environmental risk assessment
- 刊名：Journal of Proteomics
- 出版年：2016
- 出版时间：30 March 2016
- 年：2016
- 卷：137
- 期：Complete
- 页码：83-96
- 全文大小：1190 K
文摘
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We identified protein expression signatures specific of different pollutants.
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Based on these results, we develop a synthetic Integrated Biomarker Proteomic index.
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IBP follows a dose–response relationship.
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Star plots permit to discriminate the type of pollutant inducing a proteomic response.
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IBP is relevant in environmental risk assessment.