No Detrimental Effect of a Positive Family History on Long-Term Outcomes Following Radical Prostatectomy

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• 作者：Johannes M.S. Brath^a ; Sonja Grill^b ; Donna P. Ankerst^b ; Ian M. Thompson Jr.^c ; Juergen E. Gschwend^a ; Kathleen Herkommer^a ; ^{kathleen.herkommer@tum.de" class="auth_mail" title="E-mail the corresponding author}
• 关键词：survival rate ; prostatic neoplasms ; prostatectomy ; age factors ; family
• 刊名：The Journal of Urology
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：195
• 期：2
• 页码：343-348
• 全文大小：1148 K

文摘

Overall 1 in 5 patients with prostate cancer has a positive family history. In this report we evaluated the association between family history and long-term outcomes following radical prostatectomy.

Materials and Methods

Patients treated with radical prostatectomy were identified from a German registry, and separated into positive first-degree family history vs negative family history (strictly negative, requiring at least 1 male first-degree relative older than 60 years and no prostate cancer in the family). Kaplan-Meier curves and Cox proportional hazards models were used for association analyses with biochemical recurrence-free and prostate cancer specific survival.

Results

Median followup for 7,690 men included in the study was 8.4 years. Of the 754 younger patients less than 55 years old 50.9% (384) had a family history compared to 40.4% of the older patients (2,803; p <0.001). The 10-year biochemical recurrence-free (62.5%) and prostate cancer specific survival (96.1%) rates did not differ between patients with vs without a family history, nor between the younger vs older patient groups (all p >0.05). Prostate specific antigen, pathological stage, node stage and Gleason score were the only significant predictors for biochemical recurrence-free survival, while pathological stage, node stage (all p <0.005) and Gleason score (Gleason 7 vs 6 or less—HR 1.711, 95% CI 1.056–2.774, p = 0.03; Gleason 8 or greater vs 6 or less—HR 4.516, 95% CI 2.776–7.347, p <0.0001) were the only predictors for prostate cancer specific survival.

Conclusions

A family history of prostate cancer has no bearing on long-term outcomes after radical prostatectomy.