PolyMorphine: An innovative biodegradable polymer drug for extended pain relief
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- 作者：Roselin Rosario-Mel¨¦ndez ; Carolyn L. Harris ; Roberto Delgado-Rivera ; Lei Yu ; Kathryn E. Uhrich
- 关键词：Morphine ; Biodegradable ; Polymer ; Extended release ; Pain treatment ; Prodrug
- 刊名：Journal of Controlled Release
- 出版年：2012
- 出版时间：28 September, 2012
- 年：2012
- 卷：162
- 期：3
- 页码：538-544
- 全文大小：769 K
文摘
Morphine, a potent narcotic analgesic used for the treatment of acute and chronic pain, was chemically incorporated into a poly(anhydride-ester) backbone. The polymer termed ¡°PolyMorphine¡±, was designed to degrade hydrolytically releasing morphine in a controlled manner to ultimately provide analgesia for an extended time period. PolyMorphine was synthesized via melt-condensation polymerization and its structure was characterized using proton and carbon nuclear magnetic resonance spectroscopies, and infrared spectroscopy. The weight-average molecular weight and the thermal properties were determined. The hydrolytic degradation pathway of the polymer was determined by <em>in vitroem> studies, showing that free morphine is released. <em>In vitroem> cytocompatibility studies demonstrated that PolyMorphine is non-cytotoxic towards fibroblasts. <em>In vivoem> studies using mice showed that PolyMorphine provides analgesia for 3 days, 20 times the analgesic window of free morphine. The animals retained full responsiveness to morphine after being subjected to an acute morphine challenge.