New treatment for invasive fungal sinusitis: Three cases of chronic invasive fungal sinusitis treated with surgery and voriconazole

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• 作者：Kazuhiro Nakaya ; Takeshi Oshima ; Takayuki Kudo ; Iori Aoyagi ; Yukio Katori ; Jun Ota ; Hiroshi Hidaka ; Kiyoshi Oda ; Toshimitsu Kobayashi
• 关键词：Chronic invasive fungal sinusitis ; Voriconazole ; Amphotericin B
• 刊名：Auris Nasus Larynx
• 出版年：2010
• 出版时间：April 2010
• 年：2010
• 卷：37
• 期：2
• 页码：244-249
• 全文大小：1091 K

文摘

Invasive fungal sinusitis is a relatively rare disease and can be divided into acute fulminant, chronic, and granulomatous invasive fungal sinusitis. The conventional treatment is radical surgery combined with systemic amphotericin B administration, but the poor prognosis and unestablished treatment options require a better therapeutic strategy. We report three cases of chronic invasive fungal sinusitis successfully treated with a combination of surgery and voriconazole, a new antifungal agent, with good responses in all patients. Voriconazole administration could form the basis for a new standard treatment for invasive fungal sinusitis.