CSF and plasma adipokines after tonic-clonic seizures

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• 作者：Johanna Palmio^a ; ^b ; ^{johanna.palmio@uta.fi" class="auth_mail" title="E-mail the corresponding author} ; Katriina Vuolteenaho^c ; ^{katriina.vuolteenaho@uta.fi" class="auth_mail" title="E-mail the corresponding author} ; Kai Lehtimä ; ki^d ; ^{kai.lehtimaki@pshp.fi" class="auth_mail" title="E-mail the corresponding author} ; Riina Nieminen^c ; ^{riina.nieminen@uta.fi" class="auth_mail" title="E-mail the corresponding author} ; Jukka Peltola^a ; ^{jukka.peltola@pshp.fi" class="auth_mail" title="E-mail the corresponding author} ; Eeva Moilanen^c ; ^{eeva.moilanen@uta.fi" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Adiponectin ; Cerebrospinal fluid ; Epilepsy ; Leptin ; Plasma ; Tonic&ndash ; clonic seizure
• 刊名：Seizure
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：39
• 期：Complete
• 页码：10-12
• 全文大小：309 K

文摘

Adipokines, especially leptin and adiponectin, have gained increasing importance in pathophysiology of various neurological diseases including epilepsy. There are experimental data suggesting a role for leptin in the genesis of seizures and neuroprotection related to seizures. However there are no clinical studies on the effects of epileptic seizures on adipokines.

Methods

We measured cerebrospinal fluid (CSF) and plasma levels of leptin, adiponectin and adipsin after provoked or unprovoked primary or secondarily generalized tonic–clonic seizures in 13 female patients and seven controls. The samples were taken within 24 h after the seizure onset.

Results

Leptin plasma levels correlated negatively with the time to sample withdrawal, i.e. the longer the time interval between the seizure and the sample the lower the leptin levels in the patients. Interestingly, plasma adiponectin levels were significantly increased after the seizure episode.

Conclusion

This study provides further evidence that there are seizure-induced acute changes in adipokine metabolism. Leptin concentrations seem to decrease during the first 24 h after the seizure whereas adiponectin levels increase. The meaning of this response is far from clear, but it might be an endogenous attempt to prevent harmful effects of epileptic seizures in the central nervous system.