Tube feeding with a diabetes-specific feed for 12 weeks improves glycaemic control in type 2 diabetes patients

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• 作者：Nachum Vaisman ; Mirian Lansink ; Carlette H. Rouws ; Katrien M. van Laere ; R. Segal ; Eva Niv ; Tim E. Bowling ; Dan L. Waitzberg ; John E. Morley
• 关键词：Tube feed ; HbA1c ; Type 2 diabetes ; Long term study ; Postprandial glucose ; Diabetes-specific formula
• 刊名：Clinical Nutrition
• 出版年：2009
• 出版时间：October 2009
• 年：2009
• 卷：28
• 期：5
• 页码：549-555
• 全文大小：289 K

文摘

Summary

Background and aims

Assess longer-term (12 weeks) effects of a diabetes-specific feed on postprandial glucose response, glycaemic control (HbA1c), lipid profile, (pre)-albumin, clinical course and tolerance in diabetic patients.

Methods

In this randomized, controlled, double-blind, parallel group study 25 type 2 diabetic patients on tube feeding were included. Patients received a soy-protein based, multi-fibre diabetes-specific feed or isocaloric, fibre-containing standard feed for 12 weeks, while continuing on their anti-diabetic medication. At the beginning, after 6 and 12 weeks, several (glycaemic) parameters were assessed.

Results

The postprandial glucose response (iAUC) to the diabetes-specific feed was lower at the 1st assessment compared with the standard feed (p = 0.008) and this difference did not change over time. HbA1c decreased over time in the diabetes-specific and not in the standard feed group (treatment*time:p = 0.034): 6.9 ± 0.3 % (mean ± SEM) at baseline vs. 6.2 ± 0.4 % at 12 weeks in the diabetes-specific group compared to 7.9 ± 0.3 % to 8.7 ± 0.4 % in the standard feed group. No significant treatment*time effect was found for fasting glucose, insulin, (pre-) albumin or lipid profile, except for increase of HDL in the diabetes-specific group.

Conclusions

The diabetes-specific feed studied significantly improved longer-term glycaemic control in diabetic patients. This was achieved in addition to on-going anti-diabetic medication and may affect clinical outcome.