- 作者：Stephan Polterauer ; Veronika Seebacher ; Katrin Hefler-Frischmuth ; Christoph Grimm ; Georg Heinze ; Clemens Tempfer ; Alex ; er Reinthaller ; Lukas Hefler
- 关键词：cervical cancer ; coagulation ; fibrinogen ; inflammation ; prognosis
- 刊名：American Journal of Obstetrics and Gynecology
- 出版年：2009
- 出版时间：June 2009
- 年：2009
- 卷：200
- 期：6
- 页码：647.e1-647.e7
- 全文大小：662 K
Objective
The purpose of this study was to evaluate the association between fibrinogen plasma levels on disease-free patients and overall survival in patients with cervical cancer.Study Design
Pretherapeutic fibrinogen plasma levels were examined in 313 patients with cervical cancer who were treated at the Department of Obstetrics and Gynecology, Medical University of Vienna. Fibrinogen plasma levels were correlated with clinical-pathologic findings and patient survival.
Results
Mean (± SD) pretherapeutic fibrinogen plasma levels were 417.4 mg/dL (± 130.3 mg/dL). Elevated fibrinogen plasma levels were associated with advanced tumor stage (P < .001) and patient age (P < .001), but not with histologic type (P = .4), histologic grade (P = .1), and pelvic lymph node involvement (P = .9). In a multivariate survival analysis, fibrinogen plasma levels (P < .001 and < .001) and lymph node involvement (P < .001 and = .001), but not patients' age (P = .8 and .4) and histologic type (P = .7 and .5) were associated with overall or disease-free survival, respectively. Histologic grade was associated with disease-free (P = .01), but not with overall, survival (P = .2).
Conclusion
Fibrinogen plasma levels are an independent prognostic parameter in patients with cervical cancer.