Vipera lebetina venom nucleases
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- 作者：Katrin Trummala ; Kü ; lli Tõ ; nismä ; gia ; Anu Aaspõ ; llub ; Jü ; ri Siigura ; Ene Siigura ; ene.siigur@kbfi.ee" class="auth_mail" title="E-mail the corresponding author
- 关键词：Snake venom ; Vipera lebetina ; Endonucleases ; DNase ; RNase H1
- 刊名：Toxicon
- 出版年：2016
- 出版时间：1 September 2016
- 年：2016
- 卷：119
- 期：Complete
- 页码：39-45
- 全文大小：1394 K
文摘
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Vipera lebetina venom contains supercoiled plasmid degrading endonucleases.
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Vipera lebetina venom fraction with molecular mass of 30–35 kDa degrades RNA strand in RNA/DNA hybrid.
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The RNA/DNA-hydrolysing activity is caused by ribonuclease H1-like enzyme.
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The partial RNase H1-like enzyme coding DNA sequence has been determined from V. lebetina venom gland cDNA library.
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This is the first RNase H1-like enzyme found in snake venom.