Pulmonary and pleural inflammation after intratracheal instillation of short single-walled and multi-walled carbon nanotubes
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- 作者：Katsuhide Fujitaa ; b ; ka-fujita@aist.go.jp" class="auth_mail" title="E-mail the corresponding author ; Makiko Fukudab ; Shigehisa Endohb ; Junko Marub ; Haruhisa Katob ; c ; Ayako Nakamurac ; Naohide Shinoharaa ; b ; Kanako Uchinob ; Kazumasa Hondaa ; b
- 关键词：Single-walled carbon nanotubes (SWCNTs) ; Multi-walled carbon nanotubes (MWCNTs) ; Intratracheal instillation ; Pulmonary inflammation ; Pleural inflammation
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：22 August 2016
- 年：2016
- 卷：257
- 期：Complete
- 页码：23-37
- 全文大小：3648 K
文摘
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Short SWCNTs induced persistent pulmonary inflammation over a 90-day period following instillation.
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Pulmonary inflammation after short MWCNT instillation decreased in a time-dependent manner.
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MWCNT instillation induced greater levels of pleural inflammation than did short SWCNTs.
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Short SWCNTs and MWCNTs underwent lymphatic drainage to the mediastinal lymph nodes after pleural penetration.
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The extent and time-dependent changes of pulmonary and pleural inflammation differed following SWCNT and MWCNT instillations.