Reduced fertility with impairment of early-stage embryos observed in mice lacking Lgr4 in epithelial tissues
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- 作者：Yasuaki Mohri ; Tomohiro Umezu ; Shizu Hidema ; Hayato Tomisawa ; Atsushi Akamatsu ; Shigeki Kato ; Akihiro Nawa ; Katsuhiko Nishimori
- 关键词：Lgr4 ; K5-Cre– ; transgenic mice ; reproductive tract
- 刊名：Fertility and Sterility
- 出版年：2010
- 出版时间：December 2010
- 年：2010
- 卷：94
- 期：7
- 页码：2878-2881
- 全文大小：231 K
文摘
Lgr4 is one of the genes identified as novel G protein–coupled receptor genes designated Lgr4–Lgr8, with high homology with FSH receptor, LH receptor, and TSH receptor genes, but studies of Lgr4-mutant mice have suggested that Lgr4 has essential functions in development. This is the first report describing the relationship between the functions of Lgr4 and female reproductive systems.