A selective splicing variant of hepcidin mRNA in hepatocellular carcinoma cell lines
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- 作者：Yasumichi Tokia ; Katsunori Sasakib ; k-sasaki@asahikawa-med.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Hiroki Tanakac ; Masayo Yamamotoa ; Mayumi Hatayamaa ; Satoshi Itoa ; Katsuya Ikutaa ; Motohiro Shindoa ; Takumu Hasebea ; Shunsuke Nakajimaa ; Koji Sawadaa ; Mikihiro Fujiyaa ; Yoshihiro Torimotod ; Takaaki Ohtakee ; Yutaka Kohgoe
- 关键词：Aberrant splicing ; Hepcidin mRNA ; HAMP gene ; Hepatocellular carcinoma ; Cell lines
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：5 August 2016
- 年：2016
- 卷：476
- 期：4
- 页码：501-507
- 全文大小：1136 K
文摘
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An aberrant splicing variant of hepcidin mRNA lacking exon 2 of HAMP gene.
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Absolute quantification of hepcidin mRNA by digital PCR amplification.
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Hepatoma-derived cell lines have significant copies of variant-type hepcidin mRNA.
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Truncated preprohepcidin is secreted from cells without posttranslational cleavage.