Quantification of polychlorinated dibenzo-p-dioxins and dibenzofurans by direct injection of sample extract into the comprehensive multidimensional gas chromatograph/high-resolution time-of-flight mass spectrometer

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• 作者：Hashimoto Shunji ; Takazawa Yoshikatsu ; Fushimi Akihiro ; Ito Hiroyasu ; Tanabe Kiyoshi ; Shibata Yasuyuki ; Ubukata Masa-aki ; Kusai Akihiko ; Tanaka Kazuo ; Otsuka Hideyuki ; Anezaki Katsunori
• 关键词：Multidimensional gas chromatography ; High-resolution time-of-flight mass spectrometry ; Fast analysis ; Dioxin
• 刊名：Journal of Chromatography A
• 出版年：2008
• 出版时间：18 January 2008
• 年：2008
• 卷：1178
• 期：1-2
• 页码：187-198
• 全文大小：2304 K

文摘

Polychlorinated dibenzo-p-dioxins and dibenzofurans in crude extracts of fly ash and flue gas from municipal waste incinerators were quantified using a comprehensive multidimensional gas chromatograph (GC × GC) coupled to a high-resolution time-of-flight mass spectrometer (HR-TOFMS). For identification and quantification, we developed our own program to prepare 3D chromatograms of selected mass numbers from the data of the GC × GC/HR-TOFMS. Isolation of all congeners with a TCDD toxic equivalency factor from the other isomers by only one injection was confirmed. The instrumental detection limit of TCDD on the GC × GC/HR-TOFMS was 0.9 pg by the relative calibration method. Quantification of these substances in the crude extracts was achieved by direct injection to the GC × GC/HR-TOFMS. The results agree with the values obtained using a generic gas chromatography/high-resolution mass spectrometry (GC/HRMS) system. It was confirmed that measurement by high-resolution TOFMS and GC × GC effectively reduces interference from other chemicals.