Morphological changes of the anterior spinal artery during aortic cross-clamping and effect of prostaglandin E1 with perfusion

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• 作者：Yukiomi Fukumoto ; Yoshio Mori ; Hisato Takagi ; Hisashi Iwata ; Katsutoshi Murase ; Tadamasa Miyauchi ; Yukio Umeda ; Hajime Hirose
• 关键词：Rabbit ; Anterior spinal artery ; Aortic cross-clamping ; Charge-coupled device ; Prostaglandin E1
• 刊名：Prostaglandins and Other Lipid Mediators
• 出版年：2001
• 出版时间：September 2001
• 年：2001
• 卷：66
• 期：2
• 页码：89-97
• 全文大小：168 K

文摘

This investigation was designed to evaluate the morphological changes of anterior spinal artery (ASA) and its reaction to prostaglandinE1 (PGE1) during aortic cross-clamping. ASA during 30 min cross-clamping was observed with charge-coupled device (CCD) and ASA diameter(ASAD) was measured. Group A: Infrarenal aorta was cross-clamped. Group B: Infrarenal aorta was cross-clamped and aorta above the bifurcation was snared. The aortic segment between clamp and snare was perfused with blood. Group C: PGE1 of 100 ng/kg/min was added to perfusate of Group B. The aortic segmental pressures in group B and C were about 30 % of the proximal systolic arterial pressure and were significantly higher than distal pressure of group A. After cross-clamping, ASAD decreased about 80 % of before cross-clamping in group A. By segmental perfusion of which pressure was about 30 % of proximal systolic arterial pressure, ASAD remained almost 90 % in group B. By administration of PGE1, ASAD was significantly increased in group C. The changes of ASAD were significantly different between group A and C, and between group B and C.