Effects of intraduodenal injection of Lactobacillus brevis SBC8803 on autonomic neurotransmission and appetite in rodents

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• 作者：Yuko Horii^a ; ^{yhorii@anbas.co.jp} ; Yasukazu Nakakita^b ; Yoshiyuki Fujisaki^a ; Saori Yamamoto^c ; Nanako Itoh^c ; Koyomi Miyazaki^c ; Hirotaka Kaneda^d ; Katsutaka Oishi^c ; ^e ; Tatsuro Shigyo^b ; Katsuya Nagai^a ; ^f
• 关键词：Gastric vagal nerve activity ; Afferent-intestinal vagal nerve activity ; Serotonin ; Granisetron ; Autonomic nerve
• 刊名：Neuroscience Letters
• 出版年：2013
• 出版时间：28 February, 2013
• 年：2013
• 卷：539
• 期：Complete
• 页码：32-37
• 全文大小：616 K

文摘

Lactobacilli provide several health benefits to mammals, including humans. We previously observed that in rats, intraduodenal injection of Lactobacillus johnsonii La1 elevated efferent gastric vagal nerve activity (efferent-GVNA), while Lactobacillus paracasei ST11 suppressed efferent-GVNA, and thereby increased or decreased food intake. To determine the function of Lactobacillus brevis (SBC8803), its effect on food intake was examined by providing food containing heat-killed SBC8803 to mice. We observed that administration of SBC8803 elevated food intake. Because the afferent intestinal vagal nerve (IVN) is hypothesized to be involved in efferent-GVNA changes, we examined the effect of intraduodenal administration of heat-killed SBC8803 on efferent-GVNA and afferent-IVN activity (IVNA) in rats. In this study, we found that intraduodenal administration of heat-killed SBC8803 increased both efferent-GVNA and afferent-IVNA in rats. Moreover, IV administration of the serotonin 3 receptor antagonist granisetron eliminated the effects of SBC8803 on efferent-GVNA and afferent-IVNA. These findings suggest that heat-killed SBC8803 enhances appetite by elevating digestion and absorption abilities via changes in autonomic neurotransmission that might be mediated by the serotonin 3 receptor.