Associations of Obesity With Lipoprotein Subfractions in Japanese American, African American, and Korean Men

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• 作者：Nobutaka Hirooka ; Chol Shin ; Kamal H. Masaki ; Daniel Edmundowicz ; Jina Choo ; Emma J.M. Barinas-Mitchell ; Bradley J. Willcox ; Kim Sutton-Tyrrell ; Aiman El-Saed ; Iva Miljkovic-Gacic ; Takayoshi Ohkubo ; Katsuyuki Miura ; Hirotsugu Ueshima ; Lewis H. Kuller ; Akira Sekikawa ; ERA JUMP Study Group
• 刊名：Global Heart
• 出版年：2013
• 出版时间：September, 2013
• 年：2013
• 卷：8
• 期：3
• 页码：273-280
• 全文大小：188 K

文摘

Background

Both indices of obesity and lipoprotein subfractions contribute to coronary heart disease risk. However, associations between indices of obesity and lipoprotein subfractions remain undetermined across different ethnic groups.

Objective

This study aims to examine the associations of indices of obesity in Japanese Americans, African Americans, and Koreans with lipoprotein subfractions.

Methods

A population-based sample of 230 Japanese American, 91 African American, and 291 Korean men ages 40 to 49 was examined for indices of obesity¡ªthat is, visceral and subcutaneous adipose tissue (VAT and SAT, respectively); waist circumference; and body mass index¡ªand for lipoprotein subfractions by nuclear magnetic resonance spectroscopy. Multiple regression analyses were performed in each of the 3 ethnic groups to examine the associations of each index of obesity with lipoprotein.

Conclusions

VAT had significant positive associations with total and small low-density lipoprotein (LDL) and a significant negative association with large high-density lipoprotein (HDL) in all 3 ethnicities (p < 0.01). SAT, waist circumference, and body mass index had significant positive associations with total and small LDL in only Japanese Americans and Koreans, whereas these indices had significant inverse associations with large HDL in all ethnic groups (p < 0.01). Compared with SAT, VAT had larger R² values in the associations with total and small LDL and large HDL in all 3 ethnic groups. VAT is significantly associated with total and small LDL and large HDL in all 3 ethnic groups. The associations of SAT, waist circumference, and body mass index with lipoprotein subfractions are weaker than the associations of VAT in all 3 ethnic groups.