The characteristics of remnant lipoproteins in the fasting and postprandial plasma

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• 作者：Katsuyuki Nakajima^a ; ^b ; ^c ; ^d ; ^{nakajimak05@ybb.ne.jp} ; Takamitsu Nakano^a ; ^b ; Yoshiharu Tokita^a ; Takeaki Nagamine^a ; Shin-ichi Yatsuzuka^c ; Younosuke Shimomura^c ; Akira Tanaka^d ; Hiroyuki Sumino^e ; Makoto Nara^e ; Tetsuo Machida^e ; Masami Murakami^e
• 关键词：Chylomicron (CM) remnants ; Very low density lipoprotein (VLDL) remnants ; apoB-48 ; apoB-100 ; RLP-triglyceride (RLP-TG) ; RLP-cholesterol (RLP-C)
• 刊名：Clinica Chimica Acta
• 出版年：2012
• 出版时间：11 July, 2012
• 年：2012
• 卷：413
• 期：13-14
• 页码：1077-1086
• 全文大小：1518 K

文摘

Background

Remnant-like lipoprotein particles (RLP) have been measured by cholesterol as RLP-C for CHD risk assessment in the fasting plasma. However, RLP-triglyceride (TG) is a better marker of the characteristics of remnant lipoproteins in the postprandial plasma, especially in plasma with TG concentrations < 150 mg/dl.

Method

The RLP-TG and RLP-C concentrations in subjects undergoing a health check-up and in volunteers receiving an oral fat load were determined in the fasting and postprandial plasma. TC, TG, HDL-C, LDL-C, apoB 100, apoB48, RLP apoB-100 and RLP apoB48 were also determined.

Results

When fasting TG concentrations were < 150 mg/dl, the 95th percentile of RLP-TG was 20 mg/dl and the RLP-C 7.5 mg/dl in healthy subjects. The prevalence of RLP-TG and RLP-C above the cut-off values with a TG concentration < 150 mg/dl was significantly higher in the metabolic syndrome cases than in the controls. RLP-TG increased significantly in plasma to > 20 mg/dl after an oral fat load in cases with TG concentrations > 80 mg/dl. Further, RLP apoB100, but not RLP apoB48 was highly correlated with the increase of TG in the postprandial plasma.

Conclusion

RLP-TG and RLP-C were increased significantly above the cut-off values in the postprandial plasma in healthy volunteers from a TG concentration > 80 mg/dl. RLP apoB100, but not RLP apoB48, increased significantly when the plasma TG increased after an oral fat load despite the increase of plasma apoB48. The results show that the major lipoproteins which were increased in postprandial plasma were VLDL remnants, not CM remnants.