The majority of lipoprotein lipase in plasma is bound to remnant lipoproteins: A new definition of remnant lipoproteins
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- 作者：Koichi Satoa ; Fumikazu Okajimaa ; Kazuya Miyashitab ; Shigeyuki Imamurac ; Junji Kobayashid ; Kimber L. Stanhopee ; Peter J. Havele ; Tetsuo Machidaf ; Hiroyuki Suminof ; Masami Murakamif ; Ernst Schaeferg ; Katsuyuki Nakajimad ; e ; f ; g ; nakajimak05@ybb.ne.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：CM ; chylomicrons ; VLDL ; very low density lipoproteins ; HTGL ; hepatic triglyceride lipase ; LRP-1 ; low density lipoprotein receptor-related protein 1 ; LPL ; lipoprotein lipase ; RLP ; remnant-like lipoprotein particles ; RLP-C ; remnant-like lipoprotein particles-cholesterol ; RLP-TG ; remnant-like lipoprotein particles-triglyceride ; TC ; total cholesterol ; TG ; triglyceride ; THL ; tetrahydrolipstatin ; VLDL ; very low density lipoprotein
- 刊名：Clinica Chimica Acta
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：461
- 期：Complete
- 页码：114-125
- 全文大小：1471 K
文摘
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More than 80% of circulating LPL in pre-heparin plasma was found in RLP as RLP-LPL complex.
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RLP-LPL complex isolated from pre- and post-heparin plasma was LPL dimers but inactive form.
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When THL added in the post-heparin plasma, most LPL dimers were found specifically in the RLP.
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Active and inactive form of LPL dimers were found in non-RLP and RLP in post-heparin plasma.