Limiting glucocorticoid secretion increases the anorexigenic property of Exendin-4
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- 作者：Shin J. Lee1 ; shin-lee@ethz.ch" class="auth_mail" title="E-mail the corresponding author ; Katharina Diener1 ; Sharon Kaufman1 ; Jean-Philippe Krieger1 ; Klaus G. Pettersen1 ; Nino Jejelava1 ; Myrtha Arnold1 ; Alan G. Watts2 ; Wolfgang Langhans1
- 关键词：GLP-1 ; Exendin-4 ; Corticosterone ; Anti-dopamine-β-hydroxylase-saporin ; Hypothalamus ; Neuropeptide Y
- 刊名：Molecular Metabolism
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：5
- 期：7
- 页码：552-565
- 全文大小：2832 K
文摘
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Blocking HPA axis by low dose dexamethasone increased the anorexigenic property of Ex-4.
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Dexamethasone/Ex-4 co-treatment reduced food intake and body weight in diet-induced obese rats more than Ex-4 alone.
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A brain lesion model identified a potential central interaction between glucocorticoids and GLP-1 in food intake control.