Role of arginine and lysine in the antimicrobial mechanism of histone-derived antimicrobial peptides

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• 作者：Kara J. Cutrona¹ ; Bethany A. Kaufman ; Dania M. Figueroa ; Donald E. Elmore ; ^{delmore@wellesley.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：AMP ; antimicrobial peptide ; BF2 ; buforin II ; CD ; circular dichroism ; CPP ; cell-penetrating peptide ; HDAP ; histone-derived antimicrobial peptide
• 刊名：FEBS Letters
• 出版年：2015
• 出版时间：21 December 2015
• 年：2015
• 卷：589
• 期：24
• 页码：3915-3920
• 全文大小：638 K

文摘

<dl class="listitem" id="list_l0005"><dt class="label">•dt><dd>

d="p0005">Arginine enhances antimicrobial peptide activity compared to lysine.

dd><dt class="label">•dt><dd>

d="p0010">Both permeabilizing and translocating peptides exhibit arginine effect.

dd><dt class="label">•dt><dd>

d="p0015">Increasing arginine content is a potential strategy for antimicrobial peptide design.

dd>dl>