Allogeneic Stem Cell Transplantation Improves Survival in Patients with Acute Myeloid Leukemia Characterized by a High Allelic Ratio of Mutant FLT3-ITD
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- 作者：Anthony D. Ho1 ; &Dagger ; ; Johannes Schetelig2 ; &Dagger ; ; johannes.schetelig@uniklinikum-dresden.de" class="auth_mail" title="E-mail the corresponding author ; Tilmann Bochtler1 ; Markus Schaich2 ; Kerstin Schä ; fer-Eckart3 ; Mathias Hä ; nel4 ; Wolf Rö ; sler5 ; Hermann Einsele6 ; Martin Kaufmann7 ; Hubert Serve8 ; Wolfgang E. Berdel9 ; Matthias Stelljes9 ; Jiri Mayer10 ; Albrecht Reichle11 ; Claudia D. Baldus12 ; Norbert Schmitz13 ; Michael Kramer2 ; Christoph Rö ; llig2 ; Martin Bornhä ; user2 ; Christian Thiede2 ; &Dagger ; ; Gerhard Ehninger2 ; &Dagger ; ; on behalf of the Study Alliance Leukemia
- 关键词：Allogeneic transplantation ; Acute myeloid leukemia ; FLT3-ITD ; NPM1 mutation
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：22
- 期：3
- 页码：462-469
- 全文大小：493 K
文摘
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We analyzed the role of alloHCT in patients with AML depending on the ratio of mutant to wild-type FLT3 alleles.
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According to a predefined cutoff for the allelic ratio for mutant to wild-type <em>FLT3-ITDem>, patients were grouped into high ratio (HR) and low ratio (LR) <em>FLT3-ITDem>.
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AlloHCT improves EFS and OS in patients with HR<em>FLT3-ITDem> but only EFS in LR<em>FLT3-ITDem> AML.