Effects of the novel norepinephrine prodrug, droxidopa, on ambulatory blood pressure in patients with neurogenic orthostatic hypotension
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- 作者：Horacio Kaufmann ; MDa ; Horacio.Kaufmann@nyumc.org" class="auth_mail" title="E-mail the corresponding author ; Lucy Norcliffe-Kaufmann ; PhDa ; L. Arthur Hewitt ; PhDb ; Gerald J. Rowse ; PhDb ; 1 ; William B. White ; MDc
- 关键词：Circadian rhythm ; clinical trials ; supine hypertension
- 刊名：Journal of the American Society of Hypertension
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：10
- 期：10
- 页码：819-826
- 全文大小：336 K
文摘
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Twenty-four hour blood pressures (BPs) were compared on droxidopa treatment versus off drug in patients with neurogenic orthostatic hypotension.
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Droxidopa significantly increased 24-hour and daytime BP in patients with neurogenic orthostatic hypotension.
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Droxidopa increased nighttime BP to a lesser extent than increases in daytime, awake BP.
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Twenty-four hour BPs can detect patients at risk of supine hypertension to adjust treatment.