Polysaccharides from Gracilaria corticata

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• 作者：Kausik Chattopadhyay ; Tuhin Ghosh ; Carlos A. Pujol ; Marí ; a J. Carlucci ; Elsa B. Damonte ; Bimalendu Ray
• 关键词：Gracilaria corticata ; Galactan sulfate ; Anti-HSV activity
• 刊名：International Journal of Biological Macromolecules
• 出版年：2008
• 出版时间：1 November 2008
• 年：2008
• 卷：43
• 期：4
• 页码：346-351
• 全文大小：319 K

文摘

In this study, we have analyzed water-extracted polysaccharides of Gracilaria corticata. The water extract (WE), a galactan-containing sub-fraction (F3) and their hyper sulfated derivatives (WES1, WES2, F3S1 and F3S2) had anti-HSV activity with inhibitory concentration 50 % (IC₅₀) from 1.1 to 27.4 μg/ml. Sub-fraction F3, which has a molecular mass of 30 kDa, consists of a backbone of β-(1 → 3) and α-(1 → 4)-linked-galactopyranosyl residues. This linear galactan contained Gal₂Xyl₁, Gal₂AnGal₂, Gal₄ and Me-Gal₃AnGal₂ as oligomeric building subunits. Sulfate group was located at C-4 of (1 → 3)-linked galactopyranosyl residues of the native galactan, and appeared to be very important for the anti-herpetic activity.