A pediatric patient with myopathy associated with antibodies to a signal recognition particle
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- 作者：Takayoshi Kawabata ; Hirofumi Komaki ; Takashi Saito ; Yoshiaki Saito ; Eiji Nakagawa ; Kenji Sugai ; Masayuki Sasaki ; Yukiko K. Hayashi ; Ichizo Nishino ; Mei Momomura ; Toshitaka Kizawa ; Tomoyuki Imagawa ; Shumpei Yokota
- 关键词：Signal recognition particle ; Anti-SRP myopathy ; Muscular dystrophy ; Inflammatory myopathy ; Myositis ; Muscle pathological findings
- 刊名：Brain and Development
- 出版年：2012
- 出版时间：November, 2012
- 年：2012
- 卷：34
- 期：10
- 页码：877-880
- 全文大小：331 K
文摘
We report the case of a 15-year-old Japanese girl with myopathy associated with antibodies to a signal recognition particle (anti-SRP myopathy). The patient presented with progressive symmetrical proximal muscle weakness that caused difficulty in walking within 3 months, and marked elevation of the serum creatine kinase levels. A skeletal muscle biopsy revealed active necrotic and regenerating processes, with mild inflammatory changes. Based on the above findings, the patient was diagnosed as having anti-SRP myopathy. Only a limited number of pediatric patients with anti-SRP myopathy has been reported previously, with usually a poor prognosis. Early diagnosis is important for obtaining a better prognosis in patients with anti-SRP myopathy.