Protective effects of the complex between manganese porphyrins and catalase-poly(ethylene glycol) conjugates against hepatic ischemia/reperfusion injury in vivo
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- 作者：Tomochika Hanawa ; Shoichiro Asayama ; Taiji Watanabe ; Shigeru Owada ; Hiroyoshi Kawakami
- 关键词：Superoxide dismutase mimic ; Manganese porphyrin ; Catalase-poly(ethylene glycol) conjugate ; Hepatic ischemia/reperfusion injury ; Antioxidative activity
- 刊名：Journal of Controlled Release
- 出版年：2009
- 出版时间：2 April 2009
- 年：2009
- 卷：135
- 期：1
- 页码：60-64
- 全文大小：439 K
文摘
The complex between manganese (Mn) porphyrins and catalase-poly(ethylene glycol) (PEG) conjugates has been designed for the protective effect against hepatic ischemia/reperfusion injury in vivo. The resulting Mn-porphyrin/catalase-PEG complex with dual enzymatic activity of superoxide dismutase (SOD) and catalase enhanced the blood circulation. The spin reduction rate in the rats treated with the Mn-porphyrin/catalase-PEG complex was significantly higher than that in the untreated rats and almost equal to that in the sham group rats. Furthermore, the Mn-porphyrin/catalase-PEG complex significantly decreased the serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. These results suggest that the Mn-porphyrin/catalase-PEG complex exhibited the antioxidative activity to protect hepatic ischemia/reperfusion injury in vivo.