Cholecystokinin-8 (CCK-8) has no effect on heart rate in rats lacking CCK-A receptors
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- 作者：Kurosawa ; Mieko ; Iijima ; Setsu ; Funakoshi ; Akihiro ; Kawanami ; Takako ; Miyasaka ; Kyoko ; Bucinskaite ; Violeta ; et. al.
- 关键词：Heart rate ; Cholecystokinin ; Type A CCK receptors ; Otsuka Long-Evans Tokushima Fatty (OLETF) rats ; Long-Evans Tokushima Otsuka (LETO) rats ; Atrium ; Ventricle
- 刊名：Peptides
- 出版年：2001
- 出版时间：August, 2001
- 年：2001
- 卷：22
- 期：8
- 页码：1279-1284
- 全文大小：162 K
文摘
Heart rate responses to i.v. administration of cholecystokinin-8 (CCK-8) were investigated in Otsuka Long-Evans Tokushima Fatty (OLETF) rats lacking CCK-A receptors and control Long-Evans Tokushima Otsuka (LETO) rats. The heart rate decreased after i.v. administration of 3 nmol·kg−1 of CCK-8 in LETO rats, but not in OLETF rats. Bradycardia in the LETO rats disappeared after treatment with MK-329, but not after treatment with L-365,260. The expression of CCK-A receptor precursor mRNA was found exclusively in the atrium in LETO rats. These results suggest that CCK-8 decreases heart rate via CCK-A receptors located in the atrium of the rats.