Cutaneous hidradenoma: a study of 21 neoplasms revealing neither correlation between the cellular composition and CRTC1-MAML2 fusions nor presence of CRTC3-MAML2 fusions

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• 作者：Liubov Kyrpychova ; MD^a ; Denisa Kacerovska ; MD ; PhD^a ; ^b ; Tomas Vanecek ; PhD^a ; ^b ; Petr Grossmann ; PhD^a ; ^b ; Michal Michal ; MD^a ; ^b ; Katrin Kerl ; MD^c ; Dmitry V. Kazakov ; MD ; PhD^a ; ^c ; ^{kazakov@medima.cz" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Cutaneous adnexal tumors ; Hidradenoma ; Mucoepidermoid carcinoma ; MECT1 ; MAML2
• 刊名：Annals of Diagnostic Pathology
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：23
• 期：Complete
• 页码：8-13
• 全文大小：2937 K

文摘

Twenty-one hidradenomas from 20 patients (13 female, 7 male) ranging in age from 18 to 87 years (mean, 57.75 years; median, 60 years) were studied for CRTC1-MAML2 and CRTC3-MAML2 fusions to find out whether there is a correlation between the particular cell type (polyhedral eosinophilic, clear, mucinous, epidermoid, and oncocytic) and presence the above alterations. CRTC1-MAML2 fusions were detected in 10 of the 21 neoplasms (47.6%). Fluorescence in situ hybridization for MAML2 break apart was analyzable in 13 specimens and in all these specimens was positive, including 4 tumors with no demonstrable CRTC1-MAML2 fusion. In none of the cases was a CRTC3-MAML2 fusion detected. No obvious correlation between the cellular composition and presence of t(11,19) translocation was found.