RASSF1A, RECK genotypes and haplotypes in Egyptian population with Hepatocellular carcinoma
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- 作者：Gehan Abd-Elfataha ; dr.gehansh7977@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Abdel-Naser Abdel-Atty Gad-Allahb
- 关键词：HCC ; Hepatocellular carcinoma ; RASSF ; Ras association domain family ; RECK ; reversion-inducing-cysteine-rich protein with Kazal motifs ; T.bil ; total bilirubin ; AFP ; Alpha fetoprotein ; Hb ; Hemoglobin ; ALT ; alanine transeferase ; AST ; aspartate transferase
- 刊名：Immunology Letters
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：173
- 期：Complete
- 页码：36-41
- 全文大小：681 K
文摘
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RASSF1A and RECK gene polymorphisms are risk factor for HCC in Egyptian population.
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RASFA1 A1a/Ser, Ser/Ser genotypes and Ser allele are risk factor for HCC development.
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A1a/Ser + GA haplotypes are risk factor for HCC development.
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RECK GG, G allele and haplotype A1a/A1a + GG are protective to HCC.
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HCC immune therapy can be modulated by these tumor suppressor gene polymorphisms.