Respiratory control in neonatal mice with NADPH oxidase deficiency

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• 作者：Kazemian ; Pedram ; Stephenson ; Richard ; Yeger ; Herman ; Cutz ; Ernest
• 关键词：Airways ; neuroepithelial bodies ; Channels ; K⁺ ; O₂ sensitive ; Control of breathing ; neuroepithelial bodies ; Hypoxia ; pulmonary O₂ sensor ; Mammals ; mouse ; Neuroepithelial bodies ; lung ; Oxidase ; deficiency ; knockout mouse ; Se
• 刊名：Respiration Physiology
• 出版年：2001
• 出版时间：June, 2001
• 年：2001
• 卷：126
• 期：2
• 页码：89-101
• 全文大小：250 K

文摘

A membrane bound cytochrome b₅₅₈ (NADPH oxidase) is a candidate for the oxygen sensor in pulmonary neuroepithelial bodies (NEBs) — putative airway chemoreceptors. Recent electrophysiological studies on NEB from mice with NADPH oxidase deficiency (OD; gp^91phox knock-out) have shown lack of response of O₂ sensitive K⁺ current to hypoxia challenge compared with wild-type (WT) control mice. To assess the effects of oxidase deficiency on the control of ventilation at the whole animal level, respiratory measurements were conducted under normoxic and hypoxic conditions in neonatal OD mice and compared that with the WT control group. Five-day-old OD mice were faster and shallower breathers during normoxia as well as hypoxia. In addition, the maximum hypoxic ventilatory response of the OD mice was lower than that of the WT control group and the peak increase in minute ventilation (V_max–V_normoxia) was greater in WT control than the OD mice (P