Inhibition of precancerous lesions development in kidneys by chrysin via regulating hyperproliferation, inflammation and apoptosis at pre clinical stage
详细信息 查看全文
- 作者：Summya Rashid ; Sana Nafees ; Abul Vafa ; Shekh Muhammad Afzal ; Nemat Ali ; Muneeb U. Rehman ; Syed Kazim Hasan ; Aisha Siddiqi ; Preeti Barnwal ; Ferial Majed ; Sarwat Sultana ; sarwat786@rediffmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Renal cell carcinoma ; Chrysin ; ROS ; Inflammation ; Apoptosis ; Hyper proliferation
- 刊名：Archives of Biochemistry and Biophysics
- 出版年：2016
- 出版时间：15 September 2016
- 年：2016
- 卷：606
- 期：Complete
- 页码：1-9
- 全文大小：2595 K
文摘
- •
Up regulation of inflammatory marker proteins-mechanism behind renal cancer.
- •
Increase in tumor incidences and proliferation-mechanism behind renal cancer.
- •
Down regulation of anti-oxidant armory and apoptosis-mechanism behind renal cancer.
- •
Damage in normal histological and cellular architecture.
- •
Chrysin attenuates renal carcinogenesis by modulation of above molecular pathways.