Interaction of arsenic compounds with model phospholipid membranes
详细信息 查看全文
- 作者：Mał ; gorzata Jemiola-Rzeminska ; Cecilia Rivera ; Mario Suwalsky ; Kazimierz Strzalka
- 关键词：Sodium arsenite ; Sodium arsenate ; Cacodylic acid ; Phospholipid bilayer ; Phase transition ; Differential scanning calorimetry
- 刊名：Thermochimica Acta
- 出版年：2007
- 出版时间：25 June 2007
- 年：2007
- 卷：458
- 期：1-2
- 页码：132-137
- 全文大小：397 K
文摘
This study is part of a project aimed at examining the influence of arsenic on biological membranes. By the use of differential scanning calorimetry (DSC) we have followed the thermotropic behavior of multilamellar vesicles prepared from dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylethanolamine (DMPE) upon incorporation of sodium arsenite (AsI), disodium arsenate (AsII), cacodylic acid (AsIII) and disodium methyl arsenate (AsIV).
The effectiveness of perturbations exerted by various arsenic compounds on thermotropic phase transition was further analysed in terms of thermodynamic parameters: transition temperature, enthalpy and molar heat capacity, determined for lipid/As systems on the basis of heating and cooling scans. It is found that while it only has a slight influence on the thermotropic properties of DMPC, arsenic is able to significantly modify DMPE model membranes.