Antitrypanosomal activity of some pregnane glycosides isolated from Caralluma

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• 作者：Essam Abdel-Sattar ; Naglaa G. Shehab ; Chikara Ichino ; Hiroaki Kiyohara ; Aki Ishiyama ; Kazuhiko Otoguro ; Satoshi Omura ; Haruki Yamada
• 关键词：Caralluma penicillata ; Caralluma russelliana ; Caralluma tuberculata ; Asclepiadaceae ; Penicillosides ; Russeliosides ; Caratubersides ; Antitrypanosomal activity ; Cytotoxicity
• 刊名：Phytomedicine
• 出版年：2009
• 出版时间：June 2009
• 年：2009
• 卷：16
• 期：6-7
• 页码：659-664
• 全文大小：236 K

文摘

Pregnane glycosides previously isolated from genus Caralluma (C. Penicillata, C. tuberculata and C. russelliana) were tested for their antitrypanosomal activity. Penicilloside E showed the highest antitrypanosomal activity (IC₅₀ 1.01 μg/ml) followed by caratuberside C (IC₅₀ 1.85 μg/ml), which exhibited the highest selectivity index (SI 12.04). It was noticed that acylation is required for the antitrypanosomal activity while glycosylation at C-20 has no significant effect on the activity.