Focal brain cooling terminates the faster frequency components of epileptic discharges induced by penicillin G in anesthetized rats

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• 作者：Hiroyuki Kida ; Masami Fujii ; Takao Inoue ; Yeting He ; Yuichi Maruta ; Sadahiro Nomura ; Kazuhiro Taniguchi ; Takuya Ichikawa ; Takashi Saito ; Takeshi Yamakawa ; Michiyasu Suzuki
• 关键词：Epilepsy ; Penicillin G ; Focal cooling ; Rat ; Frequency
• 刊名：Clinical Neurophysiology
• 出版年：2012
• 出版时间：September, 2012
• 年：2012
• 卷：123
• 期：9
• 页码：1708-1713
• 全文大小：1631 K

文摘

Objective

The goal of the study was to investigate the effects of focal brain cooling on epileptic discharges (EDs) and background rhythms in the sensorimotor cortex of anesthetized rats using spectral analysis of electroencephalography (EEG).

Methods

Penicillin G was administered intracortically into superficial layers of the left sensorimotor cortex and EDs were induced. Focal brain cooling was achieved using a cooling device attached to the cortical surface. The cortical surface was cooled to 25 ¡ãC, 20 ¡ãC and 15 ¡ãC, and EEG was continuously recorded just beneath the cooling device. EEG spectral powers were determined using fast Fourier transform before and during cooling.

Results

Penicillin G induced EDs and increased the Alpha and Beta power spectra. Cooling suppressed EDs with an effect that depended on the brain temperature. Cooling to 25 ¡ãC attenuated Beta powers, cooling to 20 ¡ãC attenuated Alpha and Beta powers, and cooling to 15 ¡ãC suppressed spectral powers ranging from Delta to Beta bands.

Conclusions

These results suggest that focal brain cooling can terminate EDs in the cortex and suppress spectral powers with a temperature-dependent effect.

Significance

These findings may contribute to development of a new clinical treatment for patients with epilepsy.