The impact of antigenic drift of influenza A virus on human herd immunity: Sero-epidemiological study of H1N1 in healthy Thai population in 2009

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• 作者：Yuta Kanai ; Naphatsawan Boonsathorn ; Malinee Chittaganpitch ; Guirong Bai ; Yonggang Li ; Tetsuo Kase ; Kazuo Takahashi ; Yoshinobu Okuno ; Wipawee Jampangern ; Kazuyoshi Ikuta ; Pathom Sawanpanyalert
• 关键词：Epidemiology ; Thailand ; Antibody
• 刊名：Vaccine
• 出版年：2010
• 出版时间：26 July 2010
• 年：2010
• 卷：28
• 期：33
• 页码：5437-5444
• 全文大小：578 K

文摘

To examine the effect of the antigenic drift of H1N1 influenza viruses on herd immunity, neutralization antibodies from 744 sera from Thai healthy volunteers in 2008–2009, who had not been vaccinated for at least the last 5 years, were investigated by microneutralization (MN) and hemagglutination inhibition (HI) assays. Significantly higher MN titers were observed for the H1N1 Thai isolate in 2006 than in 2008. The results indicate that the antigenically drifted virus effectively escaped herd immunity. Since the low neutralization activity of herd immunity against drifted viruses is an important factor for viruses to spread efficiently, continuous sero-epidemiological study is required for public health.