Evaluation of urinary desmosines as a noninvasive diagnostic biomarker in patients with idiopathic pleuroparenchymal fibroelastosis (PPFE)

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• 作者：Yoshiyuki Oyama^a ; Noriyuki Enomoto^a ; ^b ; ^{norieno@hama-med.ac.jp} ; Yuzo Suzuki^a ; Masato Kono^a ; Tomoyuki Fujisawa^a ; Naoki Inui^a ; ^c ; Yutaro Nakamura^a ; Shigeki Kuroishi^d ; Koshi Yokomura^e ; Mikio Toyoshima^f ; Shiro Imokawa^g ; Keiji Oishi^h ; Satoshi Watanabeⁱ ; Kazuo Kasaharaⁱ ; Tomohisa Baba^j ; Takashi Ogura^j ; Hiroshi Ishii^k ; Kentaro Watanabe^k ; Yasuhiko Nishioka^l ; Takafumi Suda^a
• 关键词：Desmosines ; Elastic fibre ; Pleuroparenchymal fibroelastosis ; Idiopathic pulmonary fibrosis
• 刊名：Respiratory Medicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：123
• 期：Complete
• 页码：63-70
• 全文大小：1198 K
• 卷排序：123

文摘

Desmosines, degradation products of mature elastin, were prospectively evaluated in patients with biopsy-proven PPFE. Urinary desmosines were measured with liquid chromatography-tandem mass spectrometry (LC-MS/MS). Levels of urinary desmosines were significantly higher in patients with PPFE than those in patients with IPF or COPD. Levels of desmosines were not correlated with physiological parameters in patients with PPFE. Urinary desmosines may be a useful diagnostic biomarker in patients with PPFE.