Hsp90-binding immunophilin FKBP51 forms complexes with hTERT enhancing telomerase activity
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- 作者：Mariana Lagadaria ; 1 ; Nadia R. Zgajnara ; 1 ; Luciana I. Gallob ; Mario D. Galignianaa ; c ; mgaligniana@conicet.gov.ar" class="auth_mail" title="E-mail the corresponding author
- 关键词：Immunophilin ; FKBP51 ; FKBP52 ; Hsp90 ; hTERT ; Telomerase
- 刊名：Molecular Oncology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：10
- 期：7
- 页码：1086-1098
- 全文大小：2472 K
文摘
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Mitochondrial FKBP51 translocates to the nucleus and colocalizes with hTERT.
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FKBP51 is a novel member of the Hsp90-based heterocomplex associated to hTERT.
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Telomerase activity is enhanced by FKBP51.
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FKBP52 is also a component of the hTERT-Hsp90 able to favor telomerase activity.