Early rescue of interneuron disease trajectory in developmental epilepsies
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- 作者：Meagan S Siehr1 ; 2 ; Jeffrey L Noebels1 ; 2 ; 3 ; jnoebels@bcm.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Current Opinion in Neurobiology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：36
- 期：Complete
- 页码：82-88
- 全文大小：625 K
文摘
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Interneuron defects are a common feature of monogenic epilepsies.
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Major modifiable targets include migration, differentiation, and excitability.
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Early intervention gene models include Arx, Dcx, Lis1, Tsc1, Pten, Kcna1, and Scn1a.
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Brain developmental programs offer effective therapeutic targets for disease modification.