Differential potassium channel gene regulation in BXD mice reveals novel targets for pharmacogenetic therapies to reduce heavy alcohol drinking

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• 作者：Jennifer A. Rinker^a ; Diana B. Fulmer^a ; Heather Trantham-Davidson^a ; Maren L. Smith^c ; Robert W. Williams^e ; Marcelo F. Lopez^b ; Patrick K. Randall^b ; L. Judson Chandler^a ; Michael F. Miles^c ; Howard C. Becker^b ; ^d ; Patrick J. Mulholland^a ; ^b ; ^{mulholl@musc.edu}
• 关键词：K+ channels ; Alcohol use disorder ; Pharmacogenetics ; BXD mice ; Prefrontal cortex ; Nucleus accumbens
• 刊名：Alcohol
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：58
• 期：Complete
• 页码：33-45
• 全文大小：1385 K
• 卷排序：58

文摘

Bioinformatic analyses found novel K+ channel genes altered by ethanol dependence. Analyses confirmed known genetic links between Kcnq, Kcnj, & Kcnn genes and alcohol. Pharmacological validation of Kcnq showed reduced alcohol drinking with retigabine. This study demonstrates the potential utility of the personalized medicine approach.