Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration
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- 作者：Russell D. Berg1 ; 9 ; Steven Levitte1 ; 2 ; 9 ; Mary P. O&rsquo ; Sullivan3 ; Seó ; nadh M. O&rsquo ; Leary3 ; C.J. Cambier4 ; 10 ; James Cameron5 ; 11 ; Kevin K. Takaki2 ; Cecilia B. Moens6 ; David M. Tobin7 ; 8 ; Joseph Keane3 ; josephmk@tcd.ie" class="auth_mail" title="E-mail the corresponding author ; Lalita Ramakrishnan2 ; 5 ; lr404@hermes.cam.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：24 March 2016
- 年：2016
- 卷：165
- 期：1
- 页码：139-152
- 全文大小：5869 K
文摘
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Lysosomal storage diseases reduce macrophage endocytic recycling and migration
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Reduced macrophage migration increases tuberculosis severity via granuloma breakdown
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Tobacco smoke particles accumulate in lysosomes of smokers’ alveolar macrophages
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Lysosomal particles reduce smokers’ macrophage migration to infecting mycobacteria